Cordyceps Blog

On Cordycepin and Cancer

Submitted by cordyceps on

 

A very interesting BBC news article (see beginning below) was released Dec. 28, 2009 on research in the UK on how Cordycepin, one of the active ingredients in Cordyceps militaris [and Ophiocordyceps sinensis] is working in fighting cancer cells. By now the full paper has been published, it is open access, although the technicality of its content makes it a bit less accessible. Here the beginning of the article:

 

Scientists discover how wild mushroom cancer drug works
Scientists have discovered how a promising cancer drug, first discovered in a wild mushroom, works. The University of Nottingham team believe their work could help make the drug more effective, and useful for treating a wider range of cancers. Cordycepin, commonly used in Chinese medicine, was originally extracted from a rare kind of parasitic mushroom that grows on caterpillars.

The researcher had extracted their cordycepin from Cordyceps militaris I was told by the researcher Cornelia de Moor, from the School of Pharmacy, University of Nottingham, Centre for Biomolecular Sciences.

 

Here a picture I took in Nantong during the 5th International Medicinal Mushroom Conference in September 2009. 

In the front C. militaris grown on rice, in the back grown on larvae. 

 

 

Geographic Genetic Diversity Study published

Submitted by cordyceps on

Late 2009 a study by Chinese researchers on the genetic diversity of Cordyceps/Ophiocordyceps sinensis on the Tibetan Plateau was published. Very interesting. I have not really studied it in detail, but the conclusion is that polymorphism of nrDNA ITS sequences suggested that O. sinensis spread from a center of origin in Kongpo (Nyingchi / Linzhi Prefecture) to Himalayan influenced southern regions of Tibet AR and subsequently spread to northern areas, where the diversity is much smaller.

title:
Genetic diversity of Ophiocordyceps sinensis, a medicinal fungus endemic to the Tibetan Plateau: Implications for its evolution and
conservation
Authors: Yongjie Zhang, Lingling Xu, Shu Zhang, Xingzhong Liu, Zhiqiang An, Mu Wang and Yinglan Guo

BMC Evolutionary Biology 2009, 9:290 doi:10.1186/1471-2148-9-290

link to the  Genetic diversity study .